Dexamethasone Sodium Phosphate (SCANCORTIN)

5 mg/mL Solution for Injection (I.V./I.M.)

This drug is highly potent and the most powerful long lasting systemic corticosteroid available in the market. The potency is 6-10 times than that of prednisone,

prednisolone and approximately 25 times more potent than the short acting product hydrocortisone. It has a duration of action ranging from 24-72 hours, with a rapid onset of action, 5 minutes after administration.

Scancortin is widely used for its powerful anti-inflammatory properties, particularly in treating severe allergic reaction, asthma and autoimmune conditions.

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Each ampoule contains:
Dexamethasone sodium phosphate equivalent to Dexamethasone phosphate 5mg

DESCRIPTION:
Scancortin contains in aqueous solution dexamethasone sodium phosphate. Dexamethasone is currently the most powerful glucocorticosteroid available in the market. Its potency is 6-10 times that of prednisone and prednisolone and 25 times that of hydrocortisone. Despite its powerful effect, however, dexamethasone has been proven to possess minimal salt and water retention properties.

ACTION:
Being a powerful glucocorticosteroid, Scancortin has strong anti-inflammatory, anti-toxic, anti-shock, anti-allergic, anti-pyretic and immunosuppressive properties. Also, the aqueous solution of Scancortin permits a rapid diffusion of the solution into the body fluids thus producing a quick penetrating effect.

INDICATIONS:
Due to its powerful and fast action, peak blood levels are reached within 5 minutes after injection, thus making it an ideal preparation for life-threatening conditions and other emergency cases.

Scancortin is highly recommended for anaphylactic shock, severe allergic reactions, fulminating infections, cerebral edema. Scancortin can also be used intrathecally in painful joints and acute rheumatic disorders. It is also indicated as a starter dose or when oral therapy is impossible or impractical.

DOSAGE:
Scancortin can be given by intravenous, intramascular, sub-cutaneous, intrathecal or by I.V. drip. Normally, one injection of 5 mg is sufficient when given daily.
However, in more serious cases, 2-3 injections may be required depending on the severity of the condition and the response of the patient. In severe cases of shock such as in toxemia or serious forms of allergies, the dosage may be increased proportionately to counteract the severe stress present.

PRECAUTION AND SIDE-EFFECTS:
Like any other glucocorticosteroid, Scancortin should also be used with caution in patients with tuberculosis, mental disorders, hypertension, cardiomyopathy, renal insufficiency, and other conditions contra-indicated to corticosteroid therapy. In cases of emergencies where the life of the patient is in danger, however, large doses may be given for short periods of time despite the presence of contraindications.

PRESENTATION:
Ampoules of 1 mL containing 5 mg. Box of 10×10’s

Disclaimer:

The information on this website is intended for educational and informational purpose only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider before making any healthcare decisions or changes to your treatment plan.

Cotrimazine (TRIZINE )

205 mg/ 45 mg per 5 mL Suspension

A drug consisting of sulfadiazine 205 mg and trimethoprim 45mg when combined in vitro, the components show high activity and a high frequency of synergy against travelers’ diarrhea, respiratory and urinary tract infections.

Cotrimazine suspension is rapidly and almost completely absorbed from the gastrointestinal tract. Peak blood concentration is reached within 1 to 4 hours.

This rapid absorption profile ensures effective blood concentrations are quickly reached, allowing the drug to act efficiently against the targeted infections.

This suspension is formulated with a pleasant orange flavor making it more palatable and suitable for children.

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FORMULATION:
Each teaspoonful (5mL) contains:
Sulfadiazine………………………….. 205 mg
Trimethoprim………………………….45 mg

DESCRIPTION:
Cotrimazine (Trizine) is a broad-spectrum antibacterial combination of sulfadiazine and trimethoprim with powerful bactericidal effects. The ideal combination of the two antibacterial components is based on the results of scientific research whereby the combination exerts a sequential blockade on two consecutive steps in the biosynthesis of nucleic acids and proteins essential to many pathogenic bacteria. The blockade results in the two components potentiating each other’s action that broadens the antibacterial spectrum and reduces the risk of the emergence of resistant strains.

Although individually, sulfadiazine and trimethoprim are bacteriostatic in nature, the combination produces a profound bactericidal action. Sulfadiazine is particularly suitable to combine with trimethoprim because of its favorable pharmacokinetic properties.

INDICATIONS:
Infections cause by gram-positive and gram-negative bacteria sensitive to sulfadiazine and trimethoprim such as respiratory and urinary tract infections. Cotrimazine’s (Trizine) broad antibacterial spectrum includes Streptococci, Staphylococci, Pneumococci, Haemophilus influenzae, Escherichia coli, Klebsiella spp and the majority of Proteus spp.

DOSAGE:
Recommended dose
Suspension

CONTRAINDICATIONS:
Hypersensitivity to sulfonamides and trimethoprim, severe liver damage, blood dyscracias e.g. megaloblastic anemia and severe renal insufficiency. Cotrimazine (Trizine) should not be given to premature and newborn babies during their first 2 months of life.

PRECAUTION:
Patient allergic to sulfonamides or trimethoprim may be allergic to sulfadiazine and trimethoprim combinations.
Patients allergic to furosemide, thiazide diuretics, sulfonylureas, or carbonic anhydrase inhibitors may be allergic to sulfonamides also.
Patients sensitive to sulfites may have an allergy to Cotrimazine (Trizine) since it contains sodium bisulfite.

SPECIAL PRECAUTIONS:
G6PD deficiency, AIDS; actual or possible folate deficiency; perform regular hematological examination; child with fragile X chromosome associated with mental retardation; discontinue in case of skin rash.

WARNING:
Use of products containing benzyl alcohol is not recommended. A fatal toxic syndrome consisting of metabolic acidosis, CNS depression,respiratory problems, renal failure, hypotension, and possibly seizures and intracranial haemorrhages has been associated with this use.

PREGNANCY AND LACTATION:
FDA Pregnancy Category C.

STORAGE:
Store at temperatures not exceeding 30°C

AVAILABILITY:
Suspension: 60 mL amber bottle

Disclaimer:

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